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TB management update

NLC 2022
Current treatment of drug-sensitive tuberculosis (TB) consists of a 6-month regimen (isoniazid, rifampicin, ethambutol, and pyrazinamide). Now, a 4-month treatment regimen with rifapentine-moxifloxacin has been suggested for patients aged 12 years and over [1]. The feasibility of a 4-month regimen in a national TB plan includes the fact that it is a treatment option which can be used in persons with human immunodeficiency virus (HIV) infection who have CD4+ cell counts ≥ 100 cells/µL and who are being treated with or are planning to use efavirenz. Rapid drug-susceptibility testing for rifampicin, fluoroquinolones and isoniazid should be performed and absorption of rifapentine in the gut is improved in the presence of high-fat foods. However, the costs may be higher for the rifapentine-moxifloxacin regimen compared with the standard 6-month regimen [2]. Carr W, et al...

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