Sarcoidosis continues to be a challenging disease for which the indication for treatment is still unclear. The measurements of treatment response are too heterogeneous and single endpoints may not be reliable (enough). There are still many questions to be answered, and for the time being, international guidelines aim to fill in the gaps as much as possible/clinically feasible.
The ATS guidelines (last update in 2020) state that the diagnosis of sarcoidosis is not standardised, but based on 3 major criteria: a compatible clinical presentation, the histological finding of non-necrotising granulomatous inflammation in ≥1 tissue samples, and the exclusion of alternative causes of granulomatous disease . Due to a lack of substantial evidence, the guidelines currently offer only 1 strong recommendation (i.e. for baseline serum calcium testing), whilst 13 conditional recommendations are made . The ERS guidelines (2021) present 12 recommendations for 7 PICOs (patients, intervention, comparison, and outcomes) and state that the major reasons for treating sarcoidosis are to lower morbidity and mortality risk and/or to improve the quality of life [2,3].
- Crouser ED, et al. Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51.
- Baughman RP, et al. Eur Respir J. 2021 Dec 16;58(6):2004079.
- Bock K. Essentials from the European Respiratory Society (2021) and the American Thoracic Society (2020) clinical practice guidelines on the diagnosis and treatment of sarcoidosis. Nordic Lung Congress 2022, 01–03 June, Copenhagen, Denmark.
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Table of Contents: NLC 2022
NLC 2022 Highlights Podcast
Respiratory Disease and Physical Activity
Physical activity improves asthma control
Tailored exercise needed for COPD patients
Exercise training for IPF patients is feasible but access needs to be improved
Respiratory Disease and Reproduction
Asthma increases risks around delivery
PRO-ART study: unravelling the link between asthma and subfertility
Early-onset and uncontrolled asthma: strong association with recurrent pregnancy loss
Palliative Care in Respiratory Diseases
Advance care planning
Biologics in Asthma
Severe asthma in the spotlights
Common comorbidities in severe asthma
Treatable Traits in Obstructive Airway Diseases
Targeting treatable traits allows a personalised approach to management of (severe) asthma
Challenges in Upper Airway Diseases
Exercise-induced laryngeal obstruction (EILO) is often misdiagnosed
The role of biologics in CRSwNP
The ULANC Group: working together in CRSwNP/asthma
Interstitial Lung Diseases (ILD)
Rheumatoid arthritis-associated ILD
Thoracic ultrasound: a new diagnostic imaging tool in RA-ILD?
Update on treatment of fibrotic ILD
Lung Cancer Screening in the Nordics
Lung cancer screening in Denmark
Points of interest for radiologists screening for lung cancer
E-cigarettes impose detrimental effects on health
Effects of passive vaping in COPD patients
Vaping amongst adolescents: an alarming trend
Tuberculosis and Sarcoidosis
New antigens in sarcoidosis
Detection of latent TB infection key to preventing the spread of the disease
New antigens in sarcoidosis
Fatigue syndrome in sarcoidosis