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New antigens in sarcoidosis

Presented By
Prof. Johan Grünewald, Karolinska Institute, Sweden
NLC 2022
In search of an effective treatment strategy for sarcoidosis, candidate antigens, Aspergillus Nidulans, and vimentin (a T-cell autoantigen), have been recently identified. Given the involvement of these antigens in the underlying mechanisms of sarcoidosis, functional analyses are currently ongoing to assess whether targeting these components could offer future therapeutic options. “The incidence of sarcoidosis in Sweden is 12/100,000 a year with 1,200 new cases a year,” explained Prof. Johan Grünewald (Karolinska Institute, Sweden). “Men show an early peak between the age of 30 to 40 years, whereas in women the peak occurs between the age of 50 to 60 years (sex hormones may play a role).” Although the origin of the disease is still largely unknown, it seems to develop as a result of a genetic predisposition in combination with external triggers (viruses, bacteria, etc.). Treatment options are limited, imposing a considerable unmet need. According ...

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