The association between asthma and decreased fertility is currently being investigated in the PRO-ART study. The outcomes are expected to provide insights into the underlying mechanism and help to increase our understanding of this complex relationship.
Asthma and sub-/infertility are among the most common chronic disorders in young adults . Moreover, women with asthma seem to experience a prolonged time of unwanted non-conception . Despite a possible association between asthma and decreased fertility, the underlying mechanisms are presently unknown. Possibly, the asthma-associated systemic inflammation may affect the reproductive organs and/or the germ cells thereby reducing fertility.
The primary objective addressed in the PRO-ART study is to investigate whether systemic treatment with omalizumab (aimed at controlling systemic asthma-related inflammation as well as at improving asthma control) may improve the pregnancy rate/outcomes in women with type2-asthma (NCT03727971). Secondary objectives include, among other, local and systemic inflammatory biomarkers and asthma control. This multicentre study has a randomised, 2-arm parallel, placebo-controlled design. The study started in January 2019, aiming to include 180 women, with the estimated study completion date of 31 December 2024 . Dr Anne Hansen (Copenhagen University Hospital, Denmark) pointed out that “The role of the men should also be considered as over the last decades the overall sperm quality has been decreasing globally. Could systemic asthma-related inflammation play a role in this decline? To get a more complete picture, further research is needed .”
- Nielsen HS, et al. Forebyggelse af nedsat frugtbarhed. København: Vidensråd for Forebyggelse. 2016:1–152. http://www.vidensraad.dk/sites/default/files/vidensraad_nedsatfrugtbarhed_digital_update-1.pdf
- Gade EJ, et al. Eur Respir J. 2016 Apr;47(4):1144-51.
- Tidemandsen C, et al. BMJ Open. 2020;10(11):e037041.
- Hansen HV. Asthma and fertility treatment. Nordic Lung Congress 2022, 01–03 June, Copenhagen, Denmark.
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Table of Contents: NLC 2022
NLC 2022 Highlights Podcast
Respiratory Disease and Physical Activity
Physical activity improves asthma control
Tailored exercise needed for COPD patients
Exercise training for IPF patients is feasible but access needs to be improved
Respiratory Disease and Reproduction
Asthma increases risks around delivery
PRO-ART study: unravelling the link between asthma and subfertility
Early-onset and uncontrolled asthma: strong association with recurrent pregnancy loss
Palliative Care in Respiratory Diseases
Advance care planning
Biologics in Asthma
Severe asthma in the spotlights
Common comorbidities in severe asthma
Treatable Traits in Obstructive Airway Diseases
Targeting treatable traits allows a personalised approach to management of (severe) asthma
Challenges in Upper Airway Diseases
Exercise-induced laryngeal obstruction (EILO) is often misdiagnosed
The role of biologics in CRSwNP
The ULANC Group: working together in CRSwNP/asthma
Interstitial Lung Diseases (ILD)
Rheumatoid arthritis-associated ILD
Thoracic ultrasound: a new diagnostic imaging tool in RA-ILD?
Update on treatment of fibrotic ILD
Lung Cancer Screening in the Nordics
Lung cancer screening in Denmark
Points of interest for radiologists screening for lung cancer
E-cigarettes impose detrimental effects on health
Effects of passive vaping in COPD patients
Vaping amongst adolescents: an alarming trend
Tuberculosis and Sarcoidosis
New antigens in sarcoidosis
Detection of latent TB infection key to preventing the spread of the disease
New antigens in sarcoidosis
Sarcoidosis guidelines update
Fatigue syndrome in sarcoidosis