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Hypoxemia and dyspnoea

NLC 2022
The relationship between hypoxemia and dyspnoea (which is a sensation of uncomfortable, difficult or laboured breathing, or the experience of breathing discomfort) can be quite complex [1]. Hypoxemia per se does not necessarily elicit dyspnoea in healthy condition, despite an increased ventilatory drive and an increased minute ventilation. The maximal sustainable ventilation for an average adult varies according to the time frame. The maximal voluntary ventilation (MVV) for 15 seconds is 130 L/min, and 75% of MVV can be maintained for 15 minutes at 100 L/min, whilst 50% of MVV can be maintained for many hours at 65 L/min. Furthermore, 30 L/min can be maintained for an almost indefinite period of time, which does not necessarily elicit dyspnoea. The ventilatory response to hypoxemia can be blunted by a number of factors such as age and diabetes, both imposing a 50% reduction in ventilatory response to hypoxemia. Similarly, fever causes a right shift in the...

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