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Fatigue syndrome in sarcoidosis

NLC 2022
A new approach to managing sarcoidosis-associated fatigue aims to facilitate increased levels of functioning, by shifting from targeting just the symptoms to targeting new coping strategies [1].

Sarcoidosis-associated fatigue is very common; it is reported in up to 90% of patients and negatively affects quality of life [2,3]. Even after remission of active disease, fatigue may persist [4]. Fatigue can be assessed by using patient-reported outcome measures (PROMS) as recommended by the guidelines, but it is important to rule out other causes of fatigue before sarcoidosis-associated fatigue can be diagnosed [5]. For patients, key implications are reassurance and to improve acceptance as well as mastery of their fatigue. In this context, exercise training is recommended for sarcoidosis patients, focusing on low-to-moderate intensity exercise as high intensity may worsen patient’s fatigue [6,7]. The ERS Guidelines also offer some advice and recommendations on managing fatigue in sarcoidosis patients [8,9].

  1. Kvale D, et al. JMIR Res Protoc. 2021 Oct 7;10(10):e32216.
  2. De Kleijn WPE, et al. Curr Opin Pulm Med. 2009;15:499-506.
  3. Voortman M, et al. Lung. 2019;197:155-161.
  4. Korenromp IHE, et al. Chest. 2011;140(2):441-447.
  5. Thunold RF, et al. Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(1):2-17.2017.
  6. Strookappe B, et al. Lung. 2015 Oct;193(5):701-8.
  7. Marcellis RGJ, et al. Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jun 22;32(1):53-62.
  8. Baughman RP, et al. Eur Respir J. 2021 Dec 16;58(6):2004079.
  9. Grongstad A. Fatigue syndrome in sarcoidosis. Nordic Lung Congress 2022, 01–03 June, Copenhagen, Denmark.


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