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Early-onset and uncontrolled asthma: strong association with recurrent pregnancy loss

Presented By
Dr Casper Tidemandsen, Copenhagen University Hospital, Denmark
NLC 2022

A Danish study investigated the association between asthma-onset and asthma control (based on asthma medication prescriptions) and pregnancy loss. Dr Casper Tidemandsen (Copenhagen University Hospital, Denmark) explained that there appears to be a stronger association between early-onset and/or uncontrolled asthma and (repeated) pregnancy loss compared with later-onset cohorts and controlled asthma, respectively.

The aim of this nationwide study was to investigate whether increased/repeated pregnancy loss in asthma was associated with the age of onset (early-onset: 6-15 y; adult-onset: 16–39 y; late-onset: 40–45 y); i.e. onset of asthma before or during the fertile age. A total of 128,553 women with asthma and 1,297,233 women without asthma in the age of 6 to 45 years were identified in the national health registers. Logistic regression analysis (adjusted for year of birth and educational level) showed that as compared with non-asthmatic women, women with asthma had odds ratios (ORs) of 1.05 (95% CI 1.03–1.07), 1.09 (95% CI 1.05–1.13), and 1.18 (95% CI 1.11–1.24) for 1, 2, and 3 or more pregnancy losses, respectively. The OR for recurrent pregnancy loss was 1.19 (95% CI 1.12–1.27). Subgroup analyses of the respective age-cohorts showed that women with early-onset asthma had an OR of 1.47 (95% CI 1.24–1.72) for ≥3 pregnancy losses. For women with uncontrolled asthma (defined as ≥400 doses of short-acting beta2 agonist per year) versus controlled asthma, a significant OR of 1.60 (95% CI 1.16-2.16) was found for ≥3 pregnancy losses [1,2].

  1. Tidemandsen C, et al. J Allergy Clin Immunol Pract. 2022 May 25;S2213-2198(22)00499-8.2022.
  2. Tidemandsen C. Asthma and recurrent pregnancy loss. Nordic Lung Congress 2022, 01–03 June, Copenhagen, Denmark.


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