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Common comorbidities in severe asthma

Presented By
Dr Asger Sverrild, Bispebjerg Hospital, Denmark
NLC 2022
Patients with severe asthma often harbour comorbidities. Atopic dermatitis and chronic rhinosinusitis with nasal polyps (CRSwNP) are common comorbidities of severe type2 asthma which respond well to treatment with biologicals targeting the underlying inflammation. Dr Asger Sverrild (Bispebjerg Hospital, Denmark) summed up the most common comorbidities in patients with severe asthma. “CRSwNP occurs in 30 to 50% of patients with severe asthma, for which the standard of care consists of intranasal steroids, systemic corticosteroids, and/or sinus surgery. Around 10–30% of patients with severe asthma have concomitant atopic dermatitis. One both FDA- and EMA-approved biological targeting the underlying type2-inflammation is currently available for the treatment of atopic dermatitis (dupilumab), and this may also be used for the treatment of asthma and/or CRSwNP. Importantly, dupilumab allows tapering off systemic corticosteroids in severe asthma (approx. 25–45 ...

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