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Predictive value of CSF Aβ and tau proteins in MS

MS Virtual 2020
A prospective study showed that 2 neurodegenerative biomarkers in cerebrospinal fluid (CSF) –beta-amyloid (Aβ) and especially tau– can help identify early-onset disability and unfavourable prognosis in MS patients, independent of age [1]. Not a single biomarker of axonal damage in MS is routinely used in clinical practice. An Italian group set out to evaluate if CSF Aβ and tau protein concentrations collected at diagnosis can predict early MS disability. They also investigated if these 2 biomarkers correlate with other radiological prognostic markers collected at baseline, i.e. global T2 white matter lesion load and spinal cord lesions. Demographic, clinical, and radiological data were collected at baseline and at the most recent clinical follow-up. Early disability was measured using the MS Severity Score (MSSS) and the MSSS age-related score (ARMSS) at the most recent follow-up. A total of 109 MS patients (82 with relapsing-remitting MS) were followed fo...

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