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Assessing demyelination using myelin water imaging

Conference
MS Virtual 2020
Myelin water imaging (MWI) is an in vivo MRI technique that images water trapped between the lipid bilayers of myelin, providing a quantitative measure of myelin: the myelin water fraction (MWF). MWI provides evidence for unique anatomical-functional relationships between myelin damage and cognition in MS. It can be used to monitor changes in myelination and its relationship to cognitive worsening or improvement [1]. This study aimed to determine possible anatomical-functional relationships between myelin content and myelin damage location and cognitive performance. A sample of 76 patients with clinically definite MS and 22 age-, sex-, and education-matched healthy controls was used. MS patients had a median EDSS of 3.2 (range 1.0 – 8.5) and median disease duration of 15.5 years (0.3 - 48.0). They all underwent cognitive testing and MRI. Cognitive testing was performed with assessments drawn from cognitive batteries validated for use in MS. Non-p...


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