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Gut dysbiosis in NMOSD promotes CNS autoimmunity

MS Virtual 2020
Neuromyelitis optica spectrum disorders (NMOSD) faecal microbiota increases susceptibility for experimental autoimmune encephalomyelitis (EAE) in a rodent model [1]. Reduction in the number of regulatory T cells may contribute to EAE exacerbation. Dysbiosis of gut microbiota has been shown both in MS and NMOSD, suggesting that the gut microbiome may regulate inflammatory responses. A San Francisco-based group hypothesised that the gut microbiota from NMOSD patients play a role in NMOSD pathogenesis. To investigate this, they colonised wild-type C57BL/6 germ-free mice with faecal samples from an untreated NMOSD patient (n=10), a household healthy control (HHC; n=9), or vehicle (n=13) for 5 weeks. In the month after that, susceptibility to MOG p35-55-induced EAE was evaluated. Results showed that EAE was more severe in mice colonised with faecal microbiota from NMOSD and HHC (3.1 and 2.6, respectively) than in mice from the vehicle group (1.9; P≤0.01)...

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