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Gut bacteria associated with relapse in paediatric-onset MS

Conference
MS Virtual 2020
A relative abundance of a gut microbiota species within the Blautia genus and its interconnected variants was associated with an elevated risk of relapse in patients with paediatric-onset MS [1]. Blautia stercoris has also been linked to disease activity in other immune-mediated diseases, such as systemic lupus erythematosus. Commensal gut microbes are known to affect host immune function and may play a role in the pathogenesis of MS. It is largely unknown to what extent gut microbiota may contribute to subsequent disease activity. To investigate this association in paediatric-onset MS patients, stool samples of 53 patients (of whom 38 girls) were collected and analysed using 16S rRNA sequencing in the V4 region. Amplicon sequence variants (ASVs) were identified using the Divisive Amplicon Denoising Algorithm-2. At the time of sample collection, mean age was 15.5 years and disease duration was 1.1 years; 48 used a disease-modifying therap...


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