11C-PIB PET allows to simultaneously map demyelination and remyelination in vivo and to generate quantitative maps of brain perfusion. In 15 relapsing-remitting MS patients, 11C-PIB PET and 3T MRI were performed at baseline and 2-4 months later. At baseline, 904 lesions were identified on T2-weighted scans. Gadolinium-enhancing lesions were excluded. Successful repair of lesions was defined as remyelination of ≥50% of demyelinated voxels, and demyelination over the follow-up in <25% of voxels that were classified as normally myelinated at study entry.
There was lower perfusion in white matter lesions than in normal-appearing white matter (0.43 vs 0.49; P<0.001). However, single-lesion R1 values were very heterogeneous (range 0.08-2.5). In single lesions, higher baseline perfusion was associated with more extensive remyelination (β=0.32; P<0.001) and reduced demyelination (β=-0.28; P<0.001). Lesion-specific perfusion at baseline was an independent predictor of successful myelin repair (OR 8.4; P<0.001).
- Colombi A, et al. Lesion-specific perfusion levels affect myelin loss and repair in multiple sclerosis: a positron emission tomography study. MSVirtual 2020, Abstract PS11.03.
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Table of Contents: MS Virtual 2020
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Positive results for vagus nerve stimulation in RA
COVID-19 and MS
Biomarkers
Treatment Strategies and Results
Management of progressive MS with approved DMT
Novel Treatment Directions
Positive results for vagus nerve stimulation in RA
Neuromyelitis Optica Spectrum Disorders
Miscellaneous Topics
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