Results from the STRENGTH trial did not indicate any primary prevention benefit of high-dose omega-3 in patients with high cardiovascular risk. There was no significant difference versus placebo for the composite outcome of major adverse cardiovascular events in this large randomised controlled trial .
Findings from the STRENGTH trial (NCT02104817) were presented by Prof. Michael Lincoff (Cleveland Clinic, USA), and were simultaneously published in JAMA [1,2]. The goal of the placebo-controlled STRENGTH trial was to evaluate the combined omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in patients with dyslipidaemia and high cardiovascular risk. The primary endpoint was a composite of cardiovascular death, non-fatal heart attack, non-fatal stroke, coronary artery revascularisation, and hospitalisation for unstable angina.
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