For patients who had discontinued statin therapy due to side effects, 90% of the symptom burden elicited by a statin challenge was also elicited by placebo . This convinced half of the study subjects to (successfully) restart statin therapy, according to results from the SAMSON trial.
Dr James Howard (Imperial College London, UK) presented the trial data, which were simultaneously published in the New England Journal of Medicine [1,2]. The highly anticipated SAMSON trial had a very original design. “This trial was designed to clarify the mystery as to why so many of our patients suffer side effects while taking statins, and yet randomised controlled trials including placebo show a similar risk of side effects, whether patients take statin or placebo tabl...
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