Patients with severe obesity (i.e. a BMI of ≥40) had more than double the risk of mechanical ventilation and a 26% higher mortality compared with normal-weight COVID-19 patients in the AHA COVID-19 Cardiovascular Disease (CVD) Registry. The mortality association was strongest in younger adults: patients aged ≤50 years with severe obesity had a 36% higher risk of death compared with their normal-weight peers .
The BMI analysis from the AHA COVID-19 CVD Registry was presented by Dr Nicholas Hendren (University of Texas Southwestern, USA). The study's hypothesis was that obesity is associated with worse outcomes in COVID-19, especially in younger patients. The primary outcome was a composite of in-hospital death or mechanical ventilation, as well as the individual components of in-hospital death and mechanical ventilation. Secondary endpoints included major adverse cardiovascular events (MACE), venous thromboembolism, and renal replacement therapy.
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