In patients with heart failure with reduced ejection fraction (HFrEF), treatment with the selective cardiac myosin-activator omecamtiv mecarbil resulted in a lower risk of a composite of heart failure and cardiovascular events, according to results from the placebo-controlled GALACTIC-HF trial .
Prof. John Teerlink (University of California, San Francisco, USA) presented the results of the GALACTIC-HF (NCT02929329) trial, which were simultaneously published in the New England Journal of Medicine . GALACTIC-HF is the first trial to test the hypothesis that selectively improving cardiac function with omecamtiv mecarbil improves outcomes in patients with HFrEF, meaning a decrease in the risk of cardiovascular death, prevention of clinical heart failure events, and improvement of symptoms. Participants were aged 18–85 years with New York Heart ...
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