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Brain irradiation as treatment option

Presented By
Prof. Corinne Faivre-Finn, The Christie NHS Foundation Trust and University of Manchester, UK
ELCC 2019
Phase 3, QUARTZ
In the radiation-oncology community, according to Prof. Corinne Faivre-Finn (The Christie NHS Foundation Trust and University of Manchester, United Kingdom), there is a falling enthusiasm for whole brain radiotherapy (WBRT). On the other hand, the benefits of stereotactic radiosurgery (SRS) are becoming evident. Currently, more targeted treatment options for patients with driver mutations are available, which changed the role of brain radiotherapy. Additionally, the boundaries of radically treatable vs controllable systemic disease are changing. Patient selection for brain radiotherapy is an interplay between multiple factors, namely: extra-cranial disease: controlled or controllable tumour and prognosis; intra-cranial disease: number, volume, and location of metastases, including mass effect; and patient-related factors: performance status, comorbidities, biology of the tumour (mainly the presence or absence of driver mutati...

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