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Stopping DMT: when or if at all?

Presented By
Prof. Ilya Kister (NYU Grossman School of Medicine, NY, USA); Prof. Gavin Giovannoni (Queen Mary University of London, UK)
Conference
ECTRIMS 2021
A hot topic session addressed the question of whether disease-modifying therapy (DMT) can be stopped at some point. In patients with relapsing-remitting MS (RRMS), older age (>55 years) and longer No Evidence of Disease Activity-3 (NEDA-3; >5 years) consistently predict a successful DMT discontinuation [1]. In progressive MS (PMS), one of the options worth considering may be a de-risking strategy, by switching onto safer immunomodulatory therapies [2]. Prof. Ilya Kister (NYU Grossman School of Medicine, NY, USA) explained during her presentation that most DMTs are approved for indefinite use, but it is unclear whether they should be used indefinitely and, if not, on which variables the decision to stop DMT should depend. Prof. Kister presented a review of over a dozen recent, retrospective, observational studies of DMT discontinuation in RRMS [1]. These studies have identified various variables that may help to predict low risk of relapse after disc...


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