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MRI more sensitive for disease activity than relapses in SPMS

Presented By
Prof. Gavin Giovannoni, Queen Mary University of London, UK
Phase 3, EXPAND
In both real-world and clinical trial setting, MRI activity was found to be a more sensitive tool to measure disease activity than relapses in secondary progressive MS (SPMS). Thus, the frequency of MRI monitoring is driving detection of disease activity. Even after 2 years without relapse and no MRI activity at baseline, disease activity returned in >50% of patients with previously ‘non-active’ MS on placebo [1]. Patients with SPMS are often categorised as active (aSPMS) or non-active (naSPMS) based on evidence of their disease activity, explained Prof. Gavin Giovannoni (Queen Mary University of London, UK). However, the relative contribution of MRI activity and/or relapses in defining disease activity is not well understood. Therefore, differences between aSPMS and naSPMS were evaluated. Data was used from the Adelphi real-world MS Disease Specific Programme (Adelphi MS DSP), and the phase 3 EXPAND study (

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