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Cortical lesions predict cognitive impairment 20 years after MS diagnosis

Presented By
Mr Stefano Ziccardi, University of Verona, Italy
Conference
ECTRIMS 2021
The number of cortical lesions at the time of MS diagnosis could accurately predict cognitive impairment 20 years after the diagnosis of the disease. A predictive model showed that patients who displayed 3 or more cortical lesions at diagnosis had a 4-fold higher risk of developing severe cognitive impairment at 20 years of follow-up [1]. Cortical lesions reflect brain damage in patients with MS [2]. However, the role of early cortical lesions in predicting long-term cognitive impairment has yet to be clarified. Therefore, the current study aimed to assess the prognostic capacity of cortical lesions at MS diagnosis regarding cognitive impairment after 20 years of MS. The study included 170 patients with MS, who received a 1.5T MRI scan within 3 years from MS diagnosis to evaluate cortical lesions. Furthermore, a neuropsychological assessment was conducted to assess cognitive status at 20 years follow-up. Mr Stefano Ziccard...


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