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T2 lesions independently predict early conversion to SPMS

Presented By
Dr Laura Lacruz-Ballester, Health Research Institute La Fe, Spain
Conference
ECTRIMS 2021
Results from a 10-year longitudinal study showed that cervical spinal cord T2 lesions independently predict early conversion to secondary progressive MS (SPMS). The occurrence and number of T2 lesions at the time of a clinically isolated syndrome (CIS) were significantly higher in patients who converted to SPMS than patients who did not. These results highlight the importance of SC-T2L at CIS diagnosis [1]. Brain MRI T2 lesions (B-T2L) at time of CIS are a well-known risk factor for developing SPMS. However, longitudinal data studying the influence of cervical spinal cord T2 lesions (SC-T2L) are lacking. The prognostic value of SC-T2L on MRI performed at the time of CIS was assessed in a retrospective study of prospectively gathered data of patients with a CIS suggestive of demyelinating disease. All participants had a brain and cervical spinal cord MRI at diagnosis. Dr Laura Lacruz-Ballester (Health Research Institute La Fe, Spain) presented the results.


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