Home > Neurology > EAN 2022 > Multiple Sclerosis > Gut microbiota composition associated with disability worsening

Gut microbiota composition associated with disability worsening

Presented By
Dr Ayla Pauwels, Vrije Universiteit Brussel, Belgium
EAN 2022
A new study found a high prevalence of dysbiotic Bacteroides 2 enterotype at baseline and after 3 months in patients with relapsing-remitting multiple sclerosis (RRMS), with additional worsening of the Expanded Disability Status Scale (EDSS) Plus score after 4–5 years. These results underscores the possible involvement of gut microbiota in MS and its potential as a prognostic biomarker. Several neurological diseases, such as MS, Parkinson's, and Alzheimer's disease, are associated with alterations in the microbiota, called dysbiosis. In the experimental autoimmune encephalomyelitis (EAE) model of MS, modulation of the gut microbiome has been shown to alter the disease [1]. Numerous studies in humans, mainly cross-sectional, have shown subtle differences in specific bacteria, but results are very diverse. By comparison, the number of longitudinal studies of gut microbiota are scarce and most failed to shed light on the possible re...

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