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Cortical lesions predict disease progression and disability accumulation

Presented By
Dr Gian Marco Schiavi, University of Verona, Italy
Conference
ECTRIMS 2021
The presence and number of cortical lesions (CLs) at the time of MS diagnosis predicted the development of secondary progressive MS (SPMS) and disability accumulation in a 20-year follow-up study. The analysis also showed that a 1.5T MRI scan at diagnosis could be used as a prognostic tool for SPMS and disease burden [1]. Recent studies have confirmed that CLs are predictive of the development of progressive MS and worsening of disability in MS patients [2,3]. The objective of this study, presented by Dr Gian Marco Schiavi (University of Verona, Italy), was to assess the prognostic value of CLs after 20 years when CLs were determined at an early stage of the disease. For this purpose, 220 patients with MS (relapsing-remitting MS, n=162; clinically isolated syndrome, n=45; primary progressive MS, n=12) were followed for a median of 20 years. At diagnosis an...


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