Home > Neurology > ECTRIMS 2021 > Imaging > Natural killer-like CD8+ T cells as a reservoir of clonal cells related to MS activity

Natural killer-like CD8+ T cells as a reservoir of clonal cells related to MS activity

Presented By
Dr Emilie Dugast, Centre de Recherche en Transplantation et Immunologie, France
Conference
ECTRIMS 2021
Memory CD8+ T cells with natural killer-like properties are increased in MS patients and associated with disease activity. These cells belong to a reservoir of oligoclonal cells that infiltrate the CNS and exert cytotoxicity independent of T-cell receptor (TCR) involvement [1]. Although memory CD8+ T cells are more predominant than CD4+ T cells in MS lesions and drive autoimmune inflammation, they have not yet been identified. The current study set out to identify a cell involved in MS with a specific phenotypic and functional pattern in the periphery subtype. Single-cell, high-dimensional profiling of peripheral memory CD8+ T cells was combined with TCRβ sequencing in a cohort of 17 MS patients and 11 healthy controls. An effector memory CD8+ T cell subtype could be identified that was increased in MS patients. Interestingly, this subtype was preferentially found during relapse epi...


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