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The role of astrocyte phenotypes in acute MS lesions

Presented By
Dr Veit Rothhammer, University of Erlangen-Nürnberg, Germany
Astrocytes have been associated with both neurodegeneration and recovery of neuronal damage in MS [1–4]. While transforming growth factor alpha (TGF-α) induces an anti-inflammatory astrocyte phenotype, vascular endothelial growth factor B (VEGF-B) induces a pro-inflammatory astrocyte polarization. Results now show that TGF-α/VEGF-B ratios can serve as a novel prognostic biomarker for acute and chronic MS lesions [5]. Dr Veit Rothhammer (University of Erlangen-Nürnberg, Germany) discussed the role of astrocyte phenotypes in acute autoimmune inflammatory CNS lesions. A key protein in the anti-inflammatory astrocyte phenotype is the aryl hydrocarbon receptor (AHR), which mediates protective effects of neural tissue and can be activated by binding of its ligands, originating from the gut microbiome or dietary factors. The activation of AHR is associate...

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