Home > Neurology > EAN 2022 > Parkinson’s Disease > Intestinal alterations in patients with Parkinson’s disease

Intestinal alterations in patients with Parkinson’s disease

Presented By
Dr Gabriele Bellini, University of Pisa, Italy
Conference
EAN 2022
Doi
https://doi.org/10.55788/7369dcc5
Patients with Parkinson’s disease (PD) can demonstrate mild intestinal inflammation, accompanied by an increase in faecal tumour necrosis factor (TNF), faecal IL-1beta, collagen fibres, and S100-expression. PD patients can also show an impairment of the intestinal epithelial barrier, expressed by an increase in acidic mucins, a decrease in Claudin-1-expression, and alterations in the microbiota. PD is characterised by alpha-synuclein accumulation, changes in gut microbiota composition, impairment of the intestinal epithelial barrier (IEB), and enteric neurogenic/immune/inflammatory changes. “The intestinal system is not only impaired by PD, but can also be a culprit,” said Dr Gabriele Bellini (University of Pisa, Italy) [1]. An imbalance in neuro-immune, brain-gut axis could lead to neuroinflammation and intestinal dysmotility. Furthermore, gut microbiota alterations, frequently found in PD patients, could very well favour bacterial translocation...


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