Home > Neurology > EAN 2022 > Epilepsy > Possible new biomarker for early neuronal death in mesial temporal lobe epilepsy

Possible new biomarker for early neuronal death in mesial temporal lobe epilepsy

Presented By
Mr Ricardo Martins-Ferreira, University of Porto, Spain
Conference
EAN 2022
Doi
https://doi.org/10.55788/3d507300
Brain-derived cell-free DNA (cfDNA) in serum of patients with mesial temporal lobe epilepsy (MTLE) may constitute a promising new biomarker for early detection of neuronal death. Notwithstanding the equal release into the bloodstream of neuron-derived cfDNA in MTLE patients and controls, differential methylation patterns could be observed. cfDNA consist of highly degraded DNA fragments that are released into the peripheral blood stream in both people with and without health conditions [1]. Apoptosis is generally considered to be the main source of cfDNA due to the matching size of cfDNA and apoptotic DNA cleavage fragments. DNA fragmentation during apoptosis is mediated by caspase-associated DNase. cfDNA in circulation presents specific DNA methylation patterns that may allow for detecting and localising cell death. Recent studies have used cell-type specificity of DNA methylation to determine the tissue of origin, thus detecting ongoing c...


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