Home > Neurology > EAN 2022 > Migraine > Targeting cortical activation by transcranial magnetic stimulation

Targeting cortical activation by transcranial magnetic stimulation

Presented By
Dr Anna Andreou, King's College London, United Kingdom
EAN 2022
Cortical spreading depression (CSD) is thought to be the underlying mechanism of the migraine aura. CSD is a slowly propagated wave of depolarisation followed by suppression of brain activity involving dramatic changes in neural and vascular function. Several studies showed that cortical stimulation can affect CSD-induced changes and act as a treatment option for migraine. CSD can be induced mechanically, chemically, or electrically, and can be used as a lab model to study cortical excitation in migraine. Cortical activation or a single CSD wave can sensitise or desensitise third-order thalamic neurons, potentially through corticothalamic modulation. Cortical activation in migraine can be targeted by transcranial magnetic stimulation (TMS). This is a non-invasive form of brain stimulation in which a changing magnetic field is used to cause an electric current at a specific brain area through electromagnetic induction. Dr Anna Andreou (King's Coll...

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