Home > Neurology > EAN 2022 > Migraine > Targeting cortical activation by transcranial magnetic stimulation

Targeting cortical activation by transcranial magnetic stimulation

Presented By
Dr Anna Andreou, King's College London, United Kingdom
Conference
EAN 2022
Doi
https://doi.org/10.55788/97ba8309
Cortical spreading depression (CSD) is thought to be the underlying mechanism of the migraine aura. CSD is a slowly propagated wave of depolarisation followed by suppression of brain activity involving dramatic changes in neural and vascular function. Several studies showed that cortical stimulation can affect CSD-induced changes and act as a treatment option for migraine. CSD can be induced mechanically, chemically, or electrically, and can be used as a lab model to study cortical excitation in migraine. Cortical activation or a single CSD wave can sensitise or desensitise third-order thalamic neurons, potentially through corticothalamic modulation. Cortical activation in migraine can be targeted by transcranial magnetic stimulation (TMS). This is a non-invasive form of brain stimulation in which a changing magnetic field is used to cause an electric current at a specific brain area through electromagnetic induction. Dr Anna Andreou (King's Coll...


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