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Tau autoimmunity associated with systemic disease

Presented By
Dr Andreia Magalhães, University of Zurich, Switzerland
EAN 2022
Tau autoimmunity is associated with vascular, kidney, and urinary disorders. A Swiss study found that anaemia, urinary disorders, chronic kidney disease, vascular disease, and diabetes are independent predictors of naturally occurring tau autoantibodies. These antibodies may be considered when evaluating Tau plasma levels in the differential diagnosis of dementia syndromes. Tau is a microtubule-binding protein that is highly expressed in neurons. It plays a pivotal role in a variety of neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and several other tauopathies. Tau antibodies against tau epitopes can reduce pathology and functional decline in animal models of tauopathies. These antibodies are currently tested in a range of clinical trials. Plasma natural anti-tau antibodies have been detected in serum and plasma of patients with Alzheimer’s disease and Parkinson’s disease, but also in ...

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