Home > Neurology > EAN 2022 > Parkinson’s Disease > Gene variants impact survival in monogenic Parkinson’s disease

Gene variants impact survival in monogenic Parkinson’s disease

Presented By
Dr Aymeric Lanore, Paris Brain Institute, France
Conference
EAN 2022
Doi
https://doi.org/10.55788/2bff76a1
Survival of patients with monogenic forms of Parkinson’s disease (PD) may be affected by specific gene mutations. The records of 2,037 PD patients were analysed from their first hospital visit and results showed that patients with LRRK2 or PRKN gene mutations had a longer survival time while the survival time was shorter for patients with SNCA or GBA gene mutations. The most common mutations causing PD are in the SNCA, LRRK2, and PRKN genes while variants in glucocerebrosidase (GBA) are considered as risk factors. Monogenic forms of PD account for approximately 5% of all cases, as most appear to occur sporadically, without any family history. A change in the LRRK2 gene is probably the most common genetic variant associated with PD, causing people who carry this variant to have a 70% risk of being diagnosed with PD by the age of 80. A study presented by Dr Aym...


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