Treatment of newly diagnosed ovarian cancer

Addition of atezolizumab to standard first-line chemotherapy did not increase progression-free survival (PFS) of patients with ovarian cancer. The SOLO1 trial showed impressive 5-year follow-up data. Platinum-taxane chemotherapy in combination with bevacizumab is an established front-line regimen for ovarian cancer in advanced stage setting. Blocking tumour-associated VEGF may promote T-cell infiltration into the tumour and boost immune responses [1]. This justifies combining anti-VEGF and anti-PD-(L)1 therapy. In the randomised, phase 3 IMagyn050 trial, 1,301 newly diagnosed patients with stage III/IV ovarian cancer (75% high-grade serous) were randomised to receive standard regimen (paclitaxel, carboplatin, bevacizumab) or the same regimen plus atezolizumab (200 mg every 3 weeks) [2]. The treatment was neoadjuvant and adjuvant (post-surgery) in 25% and 75%, respectively. There was no statistically significant PFS improvement in either the ITT pop...

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Posted on 25 November, 202024 November, 2020