PD-(L)1 is not the only immune checkpoint inhibiting anti-cancer activity of the immune system. In particular, upregulation of LAG-3 and TIM have been associated with resistance to PD-(L)1 blockade [1].
In a first-in-human phase 1 trial, the anti-PD-1 antibody Sym021 was combined with either the anti-LAG-3 antibody Sym022 or the anti-TIM antibody Sym023 [2]. A total of 70 patients with a variety of heavily pretreated, advanced tumours was treated with either Sym021 monotherapy or one of the combinations at escalating doses up to 10-20 mg/kg every 2 week. Sym021 alone or in combination with Sym022 or Sym023 was well tolerated with an adverse event profile typical of immune checkpoint inhibitors. Anti-tumour activity was observed with either Sym021 alone or in combination. Further evaluation of the anti-tumour activity of the in select tumour types post-PD-(L)1 treatment is planned. Triplet (Sym021, Sym022, Sym023) dose escalation is ongoing.
-
- Kates M, et al. Eur Urol Oncol 2019; 2588-9311(19)30025-2.
- Lakhani N, et al. Phase I studies of Sym021, an anti-PD-1 antibody, alone and in combination with Sym022 (anti-LAG-3) or Sym023 (anti-TIM-3). ESMO 2020 Virtual Meeting, abstract 1019O.
Posted on
« CRC disseminates using collective migration Next Article
Bispecific antibodies targeting PD-1 and CTLA-4: new kids on the block(ade) »
Table of Contents: ESMO 2020
Featured articles
COVID-19 and Cancer
Breast Cancer
Gastrointestinal Cancers
Lung Cancer
Melanoma
Genitourinary Cancers
Bladder cancer risk and early detection
Gynaecological Cancers
Basic Science
Related Articles
Preoperative immunotherapy in early stage NSCLC safe and feasible
Surveillance after curative treatment for CRC
Treatment of recurrent ovarian cancer
© 2021 Medicom Medical Publishers. All rights reserved. Terms and Conditions | Privacy Policy