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Consolidation ipilimumab and nivolumab in limited stage SCLC

Conference
ESMO 2020
The STIMULI trial showed no improvement in progression-free survival (PFS) with nivolumab plus ipilimumab consolidation therapy versus observation after chemoradiotherapy in limited stage small cell lung cancer (SCLC). Concurrent chemoradiotherapy (CRT) followed by prophylactic cranial irradiation (PCI) is the standard strategy in limited stage SCLC. In the phase 2 STIMULI trial, 153 patients were 1:1 randomised after completion of CRT and PCI to consolidation therapy (4 cycles of nivolumab 1 mg/kg every 3 weeks plus ipilimumab 3 mg/kg every 3 weeks, followed by nivolumab monotherapy 240 mg every 2 weeks for up to 12 months) or observation [1]. Median PFS in the nivolumab/ipilimumab arm was 10.7 months versus 14.5 months in the observation arm (HR 1.02; P=0.93). Two-year PFS rate was 43% and 40%, respectively. Median overall survival (OS) was not reached in the nivolumab/ipilimumab arm, while it was 31.6 months in the observation arm (HR 1.06; P=0.8...


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