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Adjuvant chemotherapy less effective in elderly CRC patients

ESMO 2020
A subgroup analysis of the TOSCA trial showed elderly colorectal cancer (CRC) patients (≥70 years) to benefit less from adjuvant chemotherapy compared with younger patients. TOSCA is 1 of the 6 randomised, phase 3 clinical trials of the IDEA consortium, demonstrating non-inferiority of 3 months adjuvant chemotherapy as compared with 6 months chemotherapy in patients with stage III colon cancer [1]. However, a reduced benefit of adjuvant chemotherapy for patients over the age of 70 years is suggested. Therefore, a subgroup analysis of TOSCA was performed [2]. Primary endpoint of this subgroup analysis was relapse-free interval (RFI), defined as time from randomisation to relapse or last disease evaluation. In TOSCA, 2,360 patients with stage III disease were enrolled: 1,667 aged <70 (‘younger patients’) and 693 aged ≥70 (‘elderly patients’). The elderly patients had an ECOG performance status more often equal to ...

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