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Second- and third-line treatment options in mUC

ESMO 2020
Avelumab as maintenance therapy after first-line treatment prolonged overall survival (OS) in urothelial cancer (UC). However, predictive biomarkers are not yet found. In addition, sacituzumab govitecan showed promising activity in third (or later) lines. Platinum-based chemotherapy is an active first-line regimen for advanced and mUC. However, progression-free survival (PFS) and OS are generally short because of chemotherapy resistance. The phase 3 JAVELIN Bladder 100 trial (n=700) evaluated avelumab as maintenance therapy following response or stable disease with first-line platinum-based chemotherapy in patients with advanced UC [1]. The study met its primary objective, demonstrating significantly prolonged OS with maintenance avelumab plus best supportive care versus best supportive care alone in all randomised patients and patients with PD-L1 positive tumours. In addition, an exploratory analysis of predictive biomarkers was performed to identi...

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