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Insights into pathogenesis of AD define novel therapeutic targets

Presented By
Prof. Graham Ogg & Prof. Emma Guttman-Yassky
Conference
WCD 2019

Novel insights into the pathogenesis of atopic dermatitis (AD) are leading to many new treatment options–both systemically and locally.

Prof. Graham Ogg (Oxford University, United Kingdom) pointed out that AD pathogenesis is complex, encompassing both genetic and environmental risk factors [1]. In addition, different therapeutic targets might be required for different types of AD, e.g. acute vs chronic or Western vs Asian.

In 2007, a null inactivating mutation in the filaggrin gene was recognised as an important predisposition factor for childhood eczema and eczema-associated asthma. Filaggrin null alleles are also an indicator of poor prognosis in AD, predisposing to a form of eczema that starts in early infancy and persists into adulthood [2]. In addition, dysregulation of innate and adaptive immunity plays a key role [3]. A transcriptome study of nonlesional skin and acute and chronic lesions has shown that acute disease was associated with signi...



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