Biologics have revolutionised psoriasis care and made total skin clearance an achievable goal [1]. A retrospective cohort study has shown a significant reduction for all hospital resources in the year following initiation of biologic therapy in 76 patients with severe psoriasis; and inpatient admissions was lowered by more than 80% [2]. Thus, at least some of the higher drug costs are offset by substantial reductions in the number and length of hospital admissions. “However, significant unmet needs remain with the use of biologics,” said Prof. Jonathan Barker (King´s College London, United Kingdom). They are expensive, most patients have localised disease, and they are not 100% effective in all patients. In addition, the effect diminishes with time, and there are concerns of adverse events.
Biosimilars will improve access to treatment
A huge step forward to a more cost-effective therapy is the introduction of biosimilars. They have the potential to improve access to treatment by reducing the financial burden on healthcare systems. In addition, the branded products have reduced their prices by about 20% in the United Kingdom in response to the availability of less expensive biosimilars and competition between the biosimilars themselves [3]. As Prof. Barker pointed out, a biosimilar is the same as the reference medicine with respect to the amino acid sequence and dose and route of administration. It is also highly similar to the reference with respect to structure, biological activity, efficacy, safety, and immunogenicity profile. Previous comparisons have shown no clinically meaningful differences to the reference medicine.
Access to psoriasis care is still unequal and shows a close relationship to the socioeconomic status of a country. According to the World Bank nomenclature, psoriasis is not on a list of diseases requiring public health programmes in low to middle income countries. In these countries, resource allocation for dermatology is very low, and they deal with a shortage of dermatologists. “Access to specialist care and therapy will probably remain a privilege. However, if therapy was less costly, it would be easier to fight for funding,” said Prof. Barker.
Why lifestyle still matters
Psoriasis is associated with obesity, but the direction of this causal relationship remained unclear. A recently published study investigated this relationship using genetic variants as instrumental variables for Body Mass Index (BMI) and provides evidence that a higher BMI leads to a higher risk of psoriasis [4]. Another reason for improving patient’s lifestyle is that response to biologic treatment is influenced by certain clinical factors (see Figure) [5]. Factors that do not influence treatment include alcohol consumption, CRP levels at baseline, gender, ethnicity, and geographic region. Other factors gave conflicting evidence, e.g. age and psoriasis severity. The one factor that consistently adversely affected response was an increased BMI. In contrast, there was no evidence of a causal effect of psoriasis on BMI. This highlights the importance of weight management for improvement of therapeutic outcome but also for prevention of psoriasis.
Figure: Potential factors associated with response to biologic agents in patients with psoriasis [4]
1. Barker J. 24th World Congress of Dermatology, 10-15 June 2019, Milan, Italy.
2. Fonia A, et al. Br J Dermatol 2010;163(4):807-816.
3. Aladul MI, et al. BioDrugs 2017;31(5):439-446.
4. Budu-Aggrey A, et al. PLoS Med 2019;16(1):e1002739.
5. Edson-Heredia E, et al. J Invest Dermatol 2014;134(1):18-23.
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Table of Contents: WCD 2019
Featured articles
Letter from the Editor
Insights into pathogenesis of AD define novel therapeutic targets
Treating Psoriasis in 2019
Choosing the right biologic in psoriasis
Registries – an important research tool in biologics
Atopic Dermatitis – What is New
Insights into pathogenesis of AD define novel therapeutic targets
Combinations are hot in AD treatment
Dermal Reactions to Systemic Drugs
Cutaneous adverse events due to EGFR inhibitors
Management strategies for drug-induced mucositis
Skin toxicity of immune checkpoint inhibitors
Lupus Erythematosus Today
New targets and biologics for cutaneous lupus erythematosus
Novel lupus classification will aid future research
Hidradenitis Suppurativa
Various guidelines with much overlap
Antibiotics in hidradenitis suppurativa
Biologicals beyond TNF blockade
Small Molecules – What to Expect
Novel treatment options for many dermatologic indications
Long awaited oral therapy for moderate-to-severe AD
Novel treatment options in alopecia areata and vitiligo
Optimising the Management of Keloids
Keloids: a faulty switch in wound healing?
What the future of keloid treatment could hold
Malignant Melanoma – Advances in Management
Will malignant melanoma become a curable disease?
Best of the Posters
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