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Novel selective IL-23 blocker highly effective over 2 years

Conference
WCD 2019
Trial
Phase 3, IMMhance

Results of the phase B of the IMMhance study show that more than 80% of patients continuously treated with the IL-23 inhibitor risankizumab reach complete or almost complete clearance of their psoriasis after two years [1].

The IMMhance study consisted of 2 phases: results from the first phase were previously reported, and showed that after 16 weeks of treatment, the selective IL-23 inhibitor risankizumab (n=407) met the co-primary endpoints Psoriasis Area and Severity Index (PASI) improvement by 90% and complete or almost complete clearance of skin lesions according to physicians global assessment (sPGA 0/1) vs placebo (n=100) (P<0.001). The second phase (week 28 through week 104) of this trial evaluated the efficacy and safety of continuous therapy with risankizumab vs randomised withdrawal, as well as re-treatment.

Patients who achieved sPGA 0/1 at wee...



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