Home > Dermatology > WCD 2019 > Malignant Melanoma – Advances in Management > Will malignant melanoma become a curable disease?

Will malignant melanoma become a curable disease?

Presented By
Prof. Claus Garbe; Prof. Caroline Robert
Conference
WCD 2019
Trial
COMBI-d, COMBI-v, COMBI-i, KEYNOTE-001

Melanoma therapy has been revolutionised. Five-year survival after metastatic cancer is a marker for highly likely continuous complete remission (CR), whereas 10-year survival after metastatic cancer is a marker for definitive cure [1,2]. In this respect, modern therapeutic options have proven to lead to a continuous CR, said Prof. Claus Garbe (Eberhard Karls University, Germany) [1].

In the COMBI-d and COMBI-v trials, first-line treatment with dabrafenib plus trametinib led to long-term benefit in approximately one third of the patients who had unresectable or metastatic melanoma with a BRAF V600E or V600K mutation [3]. More than a decade ago, the diagnosis of metastatic melanoma was still a death knell: long-term survival was non-existent, only 3% of patients survived for 5 years [4]. “The first glimmers of hope were seen i...



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