Injecting keloids is one of the common treatment approaches. Outcomes and relapse rates are best if different agents are combined .
Three main injectable drug classes are often used in the treatment of keloids and hypertrophic scars: corticosteroids (CS), antimetabolites (e.g. 5-fluorouracil [5-FU]), and anti-tumour agents (e.g. bleomycin) [1,2]. Among other things, steroids suppress the inflammatory process, reduce the synthesis of collagen and glycosaminoglycans, and inhibit fibroblast growth .
The most commonly used CS is triamcinolone acetonide (TAC) in a dose of 10-40 mg/mL; but different treatment intervals are reported on in literature . Used as monotherapy, CS are primarily efficacious in 50%-100% but show a substantial recurrence rate of 9%-50% . In a comparison between TAC injections and 5-FU injections over 6 months, no statistical significance was found, but 5-FU had fewer local adverse events such as skin atrophy (TAC 44% vs...
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