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Tralokinumab improves eczema and reduces staphylococcus aureus colonisation in AD

Conference
AAD 2019

The fully human, monoclonal, IL-13 blocker tralokinumab showed to be highly effective in patients with moderate-to-severe atopic dermatitis (AD) [1]. Dysregulation of cell-mediated immune response plays a key role in the pathogenesis of AD. As a result, IL-13 and other type 2 cytokines are overexpressed.

The presented phase 2b trial included 204 adult patients with moderate-to-severe AD. For 12 weeks, 3 randomised groups of study subjects were treated with either 45 mg, 150 mg, or 300 mg of tralokinumab every second week, with a fourth group receiving a placebo. All patients were on a background treatment with topical corticosteroids (WHO class 3). These steroids were applied ≥1 time daily during 2 weeks before receiving tralokinumab, and, if necessary, throughout the rest of the trial. Efficacy was assessed by the percentage of subjects reaching an Investigator’s Global Assessment (IGA) score of 0 or 1, corresponding to clear or almost clear skin with a ≥...



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