Photodynamic therapy (PDT) is an approved treatment of actinic keratosis (AK). A study showed that ablative fractional laser pretreatment can enhance its efficacy: a high laser channel density should be chosen in patients with hyperkeratotic lesions .
AK is an intraepidermal proliferation of dysplastic keratinocytes that develops in response to chronic exposure to UV radiation. There are numerous treatment methods. One of the most effective is PDT, which involves the use of a topical photosensitising agent such as methyl aminolevulinate (MAL) before exposure to an activating light source to generate reactive oxygen species that lead to cell death. However, stratum corneum is a major barrier for drug permeation, thus decreasing transdermal MAL uptake. Therefore, different pretreatment options have been assessed to enhance PDT efficacy, including microdermabrasion, microneedling, and ablative fractional laser pretreatment. The latter has been shown in a p...
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