“At the moment, hormonal therapy in acne is considered an ‘alternative treatment’,” said Dr Julie Claire Harper (Dermatology & Skin Care Center, USA) . However, both oral contraceptives and spironolactone have been shown to be effective in acne.
The oral contraceptives norgestimate, norethindrone acetate, and drospirenone have been FDA approval for women ≥15 years of age who desire contraception and are unresponsive to topical anti-acne medications. Unfortunately, all combined oral contraceptives (COCs) increase the risk of venous thromboembolism and breast cancer [2,3].
A Japanese study showed, that spironolactone is also effective in acne . In total, 64 females completed the 20-week study. All of the patients exhibited clinical improvement, which was considered excellent in 53% and good in 47% of patients . Due to the development of gynecomastia in 3 males, treatment was discontinued in all male subjects. The aldosterone antagonist sp...
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