Atopic dermatitis (AD) involves barrier defects of the epidermis as well as skin inflammation and is often characterised by a debilitating itch. The role of interleukin-1 alpha (IL-1⍺) is not yet completely understood. "It is not clear what role IL-1⍺ plays in skin, but it is already an important player in oncology," said Prof. Eric Simpson (Oregon Health & Science University, USA) during his presentation .
Upon mechanical skin irritation or keratinocyte rupture, IL-1⍺ is released, leading to migration of leucocytes into the skin with consecutive inflammation. Once released, IL-1⍺ is also thought to induce a potentiation in sensory neurons; thus, contributing to pain and itch. It also provokes matrix metalloproteinases, entailing a breakdown of the skin barrier.
The new anti-IL-1⍺ antibody bermekimab binds to all forms of IL-1⍺ and neutralises it without targeting IL-1ß. A total of 38 patients with moderate-to-severe AD who did not show adequ...
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