Home > Dermatology > AAD 2019 > Late-Breakers > Dual IL-17A and IL-17F blocker leads to unprecedented response rates in psoriasis

Dual IL-17A and IL-17F blocker leads to unprecedented response rates in psoriasis

Presented By
Dr Andrew Blauvelt, Oregon Medical Research Center, USA
Conference
AAD 2019
Trial
BE ABLE

Data from a randomised extension study showed that patients with moderate-to-severe plaque psoriasis attained durable complete and near-complete responses for more than a year with a dual inhibitor of IL-17 [1].

Both IL-17A and IL-17F are expressed in psoriasis lesional skin and have the ability to synergise with other cytokines to amplify inflammation. This is the pathogenetic rationale to block IL-17F in addition to IL-17A. Bimekizumab is an antibody that neutralises the biologic function of both.

In the original 12-week BE ABLE 1 study previously presented, therapy with bimekizumab led to rapid, substantial clinical improvements in patients with moderate-to-severe plaque psoriasis [2]. More than 70% of patients treated with 160, 320, or 480 mg bimekizumab reached an improvement of the PASI by 90% (PASI90 response) in this trial. At this year´s AAD meeting, results were presented of the phase 2b extension study BE ABLE 2 after 60 weeks of follow-u...



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