Home > Dermatology > AAD 2019 > Late-Breakers > Bruton’s tyrosine kinase inhibitor highly effective in pemphigus vulgaris

Bruton’s tyrosine kinase inhibitor highly effective in pemphigus vulgaris

Presented By
Prof. Dedee Murrell, University of New South Wales, Australia
Conference
AAD 2019

An oral inhibitor of Bruton’s tyrosine kinase (BTK) together with very low-dose prednisone induces control of disease activity in patients with pemphigus at 12 weeks. This was the shown in the phase 2 Believe-PV proof of concept study [1].

The current standard of care is high-dose corticosteroids with prednisone-equivalent doses of ≥1 mg/kg with high toxicity and/or rituximab plus moderate-to-high initial doses of corticosteroids (≥0.5-1mg/kg).

“Despite the recent FDA approval of rituximab for moderate-to-severe pemphigus, there remains an unmet need for a quick-acting, steroid-sparing, anti-inflammatory treatment for this rare disease,” said Prof. Dedee Murrell (University of New South Wales, Australia). BTK inhibition interrupts multiple signalling pathways in immune cells, but not in T cells. In this way, B cell function can be impaired without reducing B cells directly. The agent proved also to be effective in naturally occurring pemphigus in do...



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