A nationwide Taiwanese cohort study identified an augmented cancer risk in subjects with keloids when compared with those with normal wound healing .
Keloids are the result of abnormal wound healing that may happen after damage to the dermis due to trauma or injury. They are characterised by benign, fibrous proliferations that extend beyond the initial wound margins. The rationale for investigating a possible association between keloids and the risk for cancer was based on the knowledge that cancerous cell growth often starts in a sclerotic microenvironment. One focus of the investigation was placed on the occurrence of skin cancer. Data from almost 780,000 persons with an about equal distribution of males and females was analysed. In total, 17,401 adults with keloids were matched according to gender and age with 69,604 controls without keloids. Statistical identification of the relative risk for cancer was established using a Cox proportional hazards m...
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