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White matter matters in Parkinson’s disease

Presented By
Dr Guillaume Costentin & Dr Pietro G. Scamarcia
EAN 2020
Two studies presented at EAN 2020 demonstrated that longitudinal changes of microstructural white matter (WM) damage are associated with both motor and global cognitive deterioration in Parkinson’s disease (PD) [1,2]. In the first study, disruption of WM tracts and cognitive decline was found after deep brain stimulation of the subthalamic nucleus (STN-DBS). The trajectories of electrodes in STN-DBS intersected with tracts involved in different cognitive domains [1]. A group of 51 consecutive PD patients underwent neuropsychological assessment before DBS and 6 months after in on-drug/on-stimulation condition. There was a decline in global cognitive evaluation and in selective cognitive domains including episodic verbal memory, executive functions, and phonemic and semantic verbal fluency. Decline in cued recall in verbal memory correlated with the proportion of lesions of the superior longitudinal fasciculus. The second study showed that long...

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