Home > Neurology > EAN 2020 > Headache and Pain > Small fibre pathology as biomarker for fibromyalgia

Small fibre pathology as biomarker for fibromyalgia

Presented By
Dr Dimitar Evdokimov, University of WĂĽrzburg, Germany
Conference
EAN 2020
Results from a German study add further evidence to the concept of small nerve fibre impairment in fibromyalgia syndrome (FMS) as peripheral contributor to FMS pain [1]. Indications were found for systemic and local microRNA alterations in FMS, that may serve as diagnostic signatures and treatment target. Skin biopsy, quantitative sensory testing, corneal confocal microscopy, pain-related evoked potentials, and microneurography were applied in 156 FMS patients. Blood samples and keratinocyte cultures from skin punch biopsies were collected to assess potential systemic and local microRNA signatures. MicroRNAs are small molecules that regulate gene expression and  may be promising biomarkers to identify and characterise chronic pain types. In a subgroup of FMS patients, small fibre pathology including morphological, functional, and electrophysiological properties was found. In 98 patients (63%), skin innervation was abnormal and associated with diseas...


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